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KMID : 0378019800230080047
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New Medical Journal
1980 Volume.23 No. 8 p.47 ~ p.50
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Changes of Protein, Reduced and Oxidized Glutathione Levels of the Rat Kidney Following Ammonium Chloride Intoxication
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Abstract
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Toxic dose of 0.8ml of 6% ammonium chloride(NH4C1) per 100gm of BW was intraperitoneally injected into the rat either alone or following the general anesthesia with nembutal sodium. The rat was sacrificed by cutting the carotid arteries after the tonic convulsion fully developed, and the kidneys were immediately removed.
The protein content, reduced(GSH) and oxidized glutathione(GSSG) levels of the cortex was measured, and compared with the normal and control value of the nembutal anesthesia group.
The protein contents of the kidney cortex of all the groups showed significantly elevated values from the normal (p<0.01), with the highest value of 272.50± 4.26mg/ gm in the NH4C1 intoxication group and lowered value of 261.79±4.70mg/gm in the nembutal pre-anesthesized NH4CI intoxication group. Both GSH and GSSG levels of the kidney cortex in all groups showed increased values from the normal with the tendency of the highest value inth the NH4Cl group and lowered value in the nembutal and NH4CI combined group.
From the above, it may be suggested that NH4Cl intoxication is mediated by the central nervous system.
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